2021 San Francisco 49ers Football Schedule

Listed below is the 2021 San Francisco 49ers Football Schedule. Check out the game info including, opponents, times and tickets:

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Date   Opponent Time/TV Tickets
Sunday
Sep 12, 2021
Detroit Lions at Detroit Lions
Ford Field, Detroit, MI
1:00 PM ET
FOX
Won 41-33
Sunday
Sep 19, 2021
Philadelphia Eagles at Philadelphia Eagles
Lincoln Financial Field, Philadelphia, PA
1:00 PM ET
FOX
Won 17-11
Sunday
Sep 26, 2021
Green Bay Packers Green Bay Packers
Levi's Stadium, Santa Clara, CA
8:20 PM ET
NBC
Lost 30-28
Sunday
Oct 3, 2021
Seattle Seahawks Seattle Seahawks
Levi's Stadium, Santa Clara, CA
4:05 PM ET
FOX
Lost 28-21
Sunday
Oct 10, 2021
Arizona Cardinals at Arizona Cardinals
State Farm Stadium, Glendale, AZ
4:25 PM ET
FOX
Lost 17-10
Sunday
Oct 17, 2021
Bye Week
Sunday
Oct 24, 2021
Indianapolis Colts Indianapolis Colts
Levi's Stadium, Santa Clara, CA
8:20 PM ET
NBC
Lost 30-18
Sunday
Oct 31, 2021
Chicago Bears at Chicago Bears
Soldier Field Stadium, Chicago, IL
1:00 PM ET
FOX
Won 33-22
Sunday
Nov 7, 2021
Arizona Cardinals Arizona Cardinals
Levi's Stadium, Santa Clara, CA
4:25 PM ET
FOX
Lost 31-17
Monday
Nov 15, 2021
Los Angeles Rams Los Angeles Rams
Levi's Stadium, Santa Clara, CA
8:15 PM ET
ESPN
Won 31-10
Sunday
Nov 21, 2021
Jacksonville Jaguars at Jacksonville Jaguars
TIAA Bank Field, Jacksonville, FL
1:00 PM ET
FOX
Won 30-10
Sunday
Nov 28, 2021
Minnesota Vikings Minnesota Vikings
Levi's Stadium, Santa Clara, CA
4:25 PM ET
FOX
Won 34-26
Sunday
Dec 5, 2021
Seattle Seahawks at Seattle Seahawks
Lumen Field, Seattle, WA
8:20 PM ET
NBC
Lost 30-23
Sunday
Dec 12, 2021
Cincinnati Bengals at Cincinnati Bengals
Paul Brown Stadium, Cincinnati, OH
1:00 PM ET
CBS
Won 26-23 (OT)
Sunday
Dec 19, 2021
Atlanta Falcons Atlanta Falcons
Levi's Stadium, Santa Clara, CA
4:05 PM ET
CBS
Won 31-13
Thursday
Dec 23, 2021
Tennessee Titans at Tennessee Titans
Nissan Stadium, Nashville, TN
8:20 PM ET
NFLN
Lost 20-17
Sunday
Jan 2, 2022
Houston Texans Houston Texans
Levi's Stadium, Santa Clara, CA
4:05 PM ET
CBS
Won 23-7
Sunday
Jan 9, 2022
Los Angeles Rams at Los Angeles Rams
SoFi Stadium, Inglewood, CA
4:25 PM ET
FOX
Won 27-24
NFC Wild-Card Round
Sunday
Jan 16, 2022
Dallas Cowboys at Dallas Cowboys
NFC Wild-Card Round

AT&T Stadium, Arlington, TX
4:30 PM ET
CBS
Paramount+
Won 23-17
NFC Divisional Playoffs
Saturday
Jan 22, 2022
Green Bay Packers at Green Bay Packers
NFC Divisional Playoffs

Lambeau Field, Green Bay, WI
8:15 PM ET
FOX
Won 13-10
NFC Championship
Sunday
Jan 30, 2022
Los Angeles Rams at Los Angeles Rams
NFC Championship

SoFi Stadium, Inglewood, CA
6:40 PM ET
FOX
Lost 20-17
Future and Past 49ers Schedules